Optimize your biologic therapeutics for better clinical outcomes.
Selecting the best biologic for development means sifting through data on hundreds or thousands of candidates and conditions. Prometheus Panta delivers high-resolution, multi-parameter stability characterization so you can eliminate weaker candidates earlier and move forward with confidence.
Prometheus Panta combines thermal unfolding, particle sizing, and aggregation data to give you a comprehensive stability profile of your biologics.
Prometheus Panta integrates four technologies – nanoDSF, backreflection, DLS, and SLS – in a single instrument, collecting data simultaneously throughout the entire thermal ramp. It’s the only instrument that captures a full DLS profile across the thermal ramp, giving you conformational and colloidal stability information from a single 10 µl sample, without dyes or additives. With Tm precision of ±0.2°C and an unmatched F350/F330 ratio resolution of ±0.008, Prometheus Panta reveals subtle differences between candidates that other instruments miss.
Prometheus Panta supports every stage of your biologics workflow, from early screening to regulatory submission.
Whether you’re narrowing a large candidate library or optimizing a formulation buffer, reliable stability data is what drives better pipeline decisions. Prometheus Panta delivers the multi-parameter characterization you need across the full biologics development journey.
One experiment. Multiple insights. Precise multi-parameter data in a single run.
nanoDSF
Measures the thermal stability of your biologic using its intrinsic fluorescence, delivering Tm precision of ±0.2°C and F350/F330 ratio resolution of ±0.008 — revealing subtle differences between candidates that other instruments miss.
Backreflection
Monitors sample turbidity to detect the formation of large amorphous aggregates (>12.5 nm radius), giving you a clear Tturbidity value to compare candidates and formulation conditions.
Dynamic Light Scattering - DLS
Assesses particle size and polydispersity throughout the entire thermal ramp, providing continuous insight into colloidal stability as temperature increases.
Static Light Scattering - SLS
Monitors smaller aggregates and determines molecular weight, with Tscattering and B22 values that reveal self-association behavior and aggregation propensity at high concentrations.
If your biologic could talk, it would ask for a Prometheus.
“NanoTemper helps us turn challenging biophysical tasks into routine workflows. Their intuitive solutions give us reliable data faster, so our teams can focus on advancing drug candidates.”
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